3-Chloro-4-fluoroaniline

• CAS: 367-21-5
• Catalog Number: ACM367215
• Category: Aryl Fluorinated Building Blocks
• Molecular Weight: 145.56
• Molecular Formula: C6H5ClFN
• Description: 4-Fluoro-3-chloroaniline, is an organic Fluorinated building block used for the synthesis of pharmaceutical and biologically active compounds such as, novel 6-Fluorobenzothiazole-substituted pyrazole analogues, having antiinflammatory activity.
• Synonyms: 3-Chloro-4-fluorobenzenamine;CHLOROFLUOROANILINE;para-fluoro-meta-chloroaniline;Benzenamine,3-chloro-4-fluoro;4-fluoro-3-chloro-aniline
• Boiling Point: 227-228°C(lit.)
• Melting Point: 42-47ºC
• Flash Point: 149ºC
• Density: 1.226 g/cm³
• Appearance: White crystalline powder
• Hazard Codes: T
• Hazard Statements: T,Xi,Xn
• HS Code: 29214210
• LogP: 2.64250
• MDL Number: MFCD00007767
• PSA: 26.2
• Refractive Index: 1.54-1.542
• RIDADR: UN 2811
• Safety Description: 36/37/39-45-26
• Stability: Stable. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides, chloroformates. May be air-sensitive.
• Storage Conditions: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Do not expose to air. Store under an inert atmosphere.
• Supplemental Hazard Statements: H315-H319-H302-H311-H332-H301+H311+H331-H373
• Symbol: GHS08,GHS06,GHS07
• WGK Germany: 2

Synthetic Use

Upstream Synthesis Route 1

• 350-30-1

• 367-21-5

Reference: [1] Catalysis Communications, 2010, vol. 11, # 5, p. 451 - 455

Upstream Synthesis Route 2

• 350-46-9

• 367-21-5

Reference: [1] Recueil des Travaux Chimiques des Pays-Bas, 1932, vol. 51, p. 98,109
[2] Journal of the American Chemical Society, 1971, vol. 93, # 5, p. 1190 - 1198

Downstream Synthesis Route 1

• 367-21-5

• 68077-26-9

Reference: [1] Journal of Medicinal Chemistry, 1980, vol. 23, # 12, p. 1358 - 1363
[2] Patent: US2014/73631, 2014, A1,
[3] RSC Advances, 2015, vol. 5, # 100, p. 82208 - 82214
[4] RSC Advances, 2016, vol. 6, # 23, p. 19052 - 19059
[5] Patent: WO2016/81464, 2016, A1,

Downstream Synthesis Route 2

• 367-21-5

• 1435-48-9

Reference: [1]Recueil des Travaux Chimiques des Pays-Bas,1932,vol. 51,p. 98,109

Downstream Synthesis Route 3

• 367-21-5

• 156150-67-3

Reference: [1]Chemistry - A European Journal,2018,vol. 24,p. 14622 - 14626
[2]Journal of the American Chemical Society,1971,vol. 93,p. 1190 - 1198

* For details of the synthesis route, please refer to the original source to ensure accuracy.