2,4-Bis(1-Phenylethyl)Phenol

• CAS: 2769-94-0
• Catalog Number: ACM2769940
• Category: Main Products
• Molecular Weight: 302.40
• Molecular Formula: C22H22O
• Synonyms: Phenol, 2,4-bis(1-phenylethyl)-
• Appearance: Solid

Case Study

Investigation of the Antiproliferative Effects of Extract from Clerodendrum thomsoniae Balf.f. (2,4-Bis(1-Phenylethyl)Phenol as the Dominant Compound) on Breast Cancer

Ashraf, M. V. K., et al. Indian J of Pharmaceutical Educ Res, 2021, 55(1), 1-10.

This study aimed to explore the anticancer properties of ethyl acetate fractions from Clerodendrum thomsoniae Balf.f. (EACT) in female Sprague-Dawley rats. GC-MS analysis revealed that 2,4-bis(1-phenylethyl)-phenol, constituting 39% of the extract, was the primary compound identified in EACT.
Methods
Breast cancer was induced using 7,12-dimethylbenz(a)anthracene (DMBA). Two different doses of EACT (25 mg/kg and 50 mg/kg) were administered for this investigation. Then evaluated biochemical parameters alongside hematological and antioxidant measures.
Results
The EACT-treated groups exhibited a reduction in both mean tumor volume and tumor weight. Blood parameters remained within normal ranges. In both the DMBA and doxorubicin groups, malondialdehyde levels increased, whereas a significant reduction was observed in the EACT-treated groups. Additionally, catalase activity was found to be decreased in the DMBA and doxorubicin groups but maintained normal levels in those receiving EACT. Nitro and nitrate levels were elevated in the DMBA control groups, while other treatment groups showed normal levels. Doxorubicin and EACT treatments resulted in reduced necrosis and infiltration of breast tissues. The therapeutic effect of EACT was found to be dose-dependent in the treated animals, with some of the damaged breast tissue patterns returning to normal following the treatments.

2,4-Bis(1-Phenylethyl)Phenol from Garlic Identified as a Potential Inhibitor against Lung Cancer

Padmini, R., et al. Saudi Journal of Biological Sciences, 2020, 27(12), 3274-3289.

The study examined how garlic phytochemicals function as inhibitors for pre-established drug targets specific to non-small cell lung cancer (NSCLC).
Methods
The research team used gas chromatography-mass spectrometry (GC-MS) to detect the phytochemicals contained in garlic. Molecular docking analysis evaluated the binding affinity of the identified compounds to key drug targets such as EGFR, HER2, EML4-ALK, and sPLA2-IIA. The research team performed molecular dynamics simulations to analyze how stable phytochemicals remained when interacting with NSCLC drug targets and to improve understanding of the intermolecular interactions.
Key Findings
From the 12 garlic phytocompounds analyzed, three were identified as potential inhibitors: [1,4-dimethyl-7-(1-methylethyl)-2-azulenyl]phenylmethanone, 2,4-bis(1-phenylethyl)phenol, and 4,5-2H-oxazole-5-one,4-[3,5-di-t-butyl-4-methoxyphenyl] methylene-2-phenyl. The selected compounds show potential to target multiple EGFR variants while achieving dual inhibition of NSCLC drug targets. Research data points to garlic-derived phytochemicals as promising multi-target drug candidates for managing various NSCLC clinical presentations.

Custom Q&A

What is the molecular formula of 2,4-Bis(1-Phenylethyl)Phenol?

The molecular formula is C22H22O.

What are the synonyms for 2,4-Bis(1-Phenylethyl)Phenol?

The synonyms for 2,4-Bis(1-Phenylethyl)Phenol are Phenol, 2,4-bis(1-phenylethyl)- and Phenol, bis(1-phenylethyl)-.

What is the molecular weight of 2,4-Bis(1-Phenylethyl)Phenol?

The molecular weight is 302.4 g/mol.

What is the IUPAC name of 2,4-Bis(1-Phenylethyl)Phenol?

The IUPAC name is 2,4-bis(1-phenylethyl)phenol.

What is the InChI identifier of 2,4-Bis(1-Phenylethyl)Phenol?

The InChI identifier is InChI=1S/C22H22O/c1-16(18-9-5-3-6-10-18)20-13-14-22(23)21(15-20)17(2)19-11-7-4-8-12-19/h3-17,23H,1-2H3.

What is the InChIKey of 2,4-Bis(1-Phenylethyl)Phenol?

The InChIKey is RCFAHSGZAAFQJH-UHFFFAOYSA-N.

What is the Canonical SMILES of 2,4-Bis(1-Phenylethyl)Phenol?

The Canonical SMILES is CC(C1=CC=CC=C1)C2=CC(=C(C=C2)O)C(C)C3=CC=CC=C3.

What is the CAS number of 2,4-Bis(1-Phenylethyl)Phenol?

The CAS number is 2769-94-0.

What is the XLogP3-AA value of 2,4-Bis(1-Phenylethyl)Phenol?

The XLogP3-AA value is 6.1.

Is 2,4-Bis(1-Phenylethyl)Phenol a semi-standard non-polar compound?

Yes, it is a semi-standard non-polar compound.