Shen X1, Jones GO, Watson DA, Bhayana B, Buchwald SL.
J Am Chem Soc. 2010 Aug 18;132(32):11278-87. doi: 10.1021/ja104297g.We report efficient syntheses of axially chiral biaryl amides in yields ranging from 80-92%, and with enantioselectivity in the range 88-94% ee employing an asymmetric Suzuki-Miyaura process with Pd(OAc)(2) and KenPhos as ligand. These studies demonstrate that electron-rich and electron-deficient o-halobenzamides can be efficiently coupled with 2-methyl-1-naphthylboronic acid and 2-ethoxy-1-naphthylboronic acid. Read More