Jabeen F1, Shehzadi SA1, Fatmi MQ2, Shaheen S1, Iqbal L3, Afza N3, Panda SS4, Ansari FL5.
Bioorg Med Chem Lett. 2016 Feb 1;26(3):1029-38. doi: 10.1016/j.bmcl.2015.12.033. Epub 2015 Dec 11.1,4-Disubstituted-1,2,3-triazoles were synthesized by Cu(I) catalyzed click reaction, where the azides, with electron donating and electron withdrawing groups acted as 1,3-dipoles and 1-ethynyl-1-cyclohexanol served as the terminal alkyne. These synthesized triazoles were subjected to enzymatic assay which showed promising activity against α-glucosidase; 1-(2-cyano-4-nitrophenyl)-4-(1-hydroxycyclohexyl)-1H-1,2,3-triazole 3m being the most active members of the library. Read More