Cabrera M1, de Ovalle S1, Bollati-Fogolín M2, Nascimento F3, Corbelini P3, Janarelli F3, Kawano D3, Eifler-Lima VL3, González M1, Cerecetto H1.
Future Sci OA. 2015 Nov 1;1(3):FSO20. doi: 10.4155/fso.15.18. eCollection 2015.The increased activity of phase-II-detoxification enzymes, such as quinone reductase (QR) and glutation S-transferase (GST), correlates with protection against chemically induced carcinogenesis. Herein we studied 11 different chemotypes, pyrazole, 1,2,4-oxadiazole, 1,2,5-oxadiazole, 1,2,3-thiadiazole, 1,2,4-thiazole, 1,3,4-oxathiazole, thienyl hydrazone, α,β-unsaturated-oxime, α,β-unsaturated-N-oxide, coumarin and α,β-unsaturated-carbonyl, as phase-II enzymes inducers in order to identify new pharmacophores with chemopreventive activity. Read More