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Home > Product > Metal Organics > Organic Zinc > Zinc N,N-dimethylaminoethoxide

Zinc N,N-dimethylaminoethoxide | CAS Number: 51223-30-4

Catalog Number
ACM51223304
Product Name
Zinc N,N-dimethylaminoethoxide
Structure
CAS Number
51223-30-4
IUPAC Name
zinc;2-(dimethylamino)ethanolate
Synonyms
ZINC N,N-DIMETHYLAMINOETHOXIDE
Molecular Weight
241.65
Exact Mass
240.08200
Molecular Formula
C8H20N2O2Zn
Boiling Point
170ºC 0mm
Purity
96%
SMILES
CN(C)CC[O-].CN(C)CC[O-].[Zn+2]
InChIKey
IXPVQSACNVOCSR-UHFFFAOYSA-N
H-Bond Donor
0
H-Bond Acceptor
4
Safty Description
26-36/37/39
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1Ring-opened tetrahydro-γ-carbolines display cytotoxicity and selectivity with histone deacetylase isoforms.

Nepali K1, Lee HY1, Lai MJ2, Ojha R1, Wu TY3, Wu GX1, Chen MC4, Liou JP5.

Eur J Med Chem. 2016 Dec 21;127:115-127. doi: 10.1016/j.ejmech.2016.12.039. [Epub ahead of print]

This study is focused on modification of the indole moiety and the N1-zinc binding domain of tubastatin A, and the effects of such changes on biological activity. Fourteen N-substituted indoles (5-18) were synthesized and structure-activity relationship studies indicated that the change of the tetrahydro-γ-carboline in tubastatin A led to substituted indoles (compounds 7, 11, and 15) which showed significant improvements of selective inhibition for HDAC6 over HDAC1 and HDAC2 in comparison to ACY1215, a compound undergoing clinical trials. Read More

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