Vidal-Ferran A1,2, Mon I3, Bauzá A4, Frontera A4, Rovira L3.
Chemistry. 2015 Aug 3;21(32):11417-26. doi: 10.1002/chem.201501441. Epub 2015 Jun 26.Herein we report the use of polyether binders as regulation agents (RAs) to enhance the enantioselectivity of rhodium-catalyzed transformations. For reactions of diverse substrates mediated by rhodium complexes of the α,ω-bisphosphite-polyether ligands 1-5,a-d, the enantiomeric excess (ee) of hydroformylations was increased by up to 82 % (substrate: vinyl benzoate, 96 % ee), and the ee value of hydrogenations was increased by up to 5 % (substrate: N-(1-(naphthalene-1-yl)vinyl)acetamide, 78 % ee). Read More