Catalog Number
ACM11089659
Description
Tunicamycin is a mixture of homologous nucleoside antibiotic that inhibits N-linked glycosylation and blocks GlcNAc phosphotransferase (GPT). Tunicamycin causes accumulation of unfolded proteins in cell endoplasmic reticulum (ER) and induces ER stress, and causes blocking of DNA synthesis and cell cycle arrest in G1 phase. Tunicamycin inhibits gram-positive bacteria, yeasts, fungi, and viruses and has anti-cancer activity.Tunicamycin increases exosome release in cervical cancer cells.
Synonyms
tunicamycin, Tunicamycin A1, CID5607, 11089-65-9
IUPAC Name
N-[2-[3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-[2-[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl]-4,5-dihydroxyoxan-3-yl]-12-methyltridec-2-enamide
Molecular Formula
C37H60N4O16
Canonical SMILES
CC(C)CCCCCCCCC=CC(=O)NC1C(C(C(OC1OC2C(C(C(C(O2)CO)O)O)NC(=O)C)CC(C3C(C(C(O3)N4C=CC(=O)NC4=O)O)O)O)O)O
InChI Key
YJQCOFNZVFGCAF-UHFFFAOYSA-N
Appearance
White to off-white powder
Storage
Powder-20°C, 3 years; In solvent-80°C. 6 months; -20°C, 1 month.
Hazard Statements
T+: Very toxic;
Safety Description
28-37/39-45
Shipping
Can be shipped at room temperature, where not in use may vary.
Source
Streptomyces lysosuperficus
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