Sri Ramya PV1, Angapelly S1, Guntuku L2, Singh Digwal C1, Nagendra Babu B1, Naidu VG2, Kamal A3.
Eur J Med Chem. 2016 Dec 23;127:100-114. doi: 10.1016/j.ejmech.2016.12.043. [Epub ahead of print]In our endeavour towards the development of potent cytotoxic agents, a series of some new curcumin inspired indole analogues, in which indole and phenyl moieties are linked on either sides of 1,5-diaryl-1,4-pentadien-3-one system have been synthesized and characterized by spectral data. All the newly synthesized analogues were tested for their cytotoxic potential against a panel of eight cancer cell lines namely, lung (A549), breast (MDA-MB-231, BT549 and 4T1), prostate (PC-3, DU145), gastric (HGC-27) and cervical (HeLa). Read More