Finetti F1, Terzuoli E1, Donnini S1, Uva M2, Ziche M1, Morbidelli L1.
PLoS One. 2016 Dec 30;11(12):e0168727. doi: 10.1371/journal.pone.0168727. eCollection 2016.Iron oxide nanoparticles (NPs) have been proposed for many biomedical applications as in vivo imaging and drug delivery in cancer treatment, but their toxicity is an ongoing concern. When NPs are intravenously administered, the endothelium represents the first barrier to tissue diffusion/penetration. However, there is little information about the biological effects of NPs on endothelial cells. In this work we showed that cobalt-ferrite (CoFe2O4) NPs affect endothelial cell integrity by increasing permeability, oxidative stress, inflammatory profile and by inducing cytoskeletal modifications. Read More