Kubota K1, Shibata A2, Yamaguchi T3.
Eur J Pharm Sci. 2016 Apr 30;86:75-83. doi: 10.1016/j.ejps.2016.03.002. Epub 2016 Mar 8.In spite of numerous advantages, transdermal drug delivery systems are unfeasible for most drugs because of the barrier effect of the stratum corneum. Ionic liquids were recently used to enhance transdermal drug delivery by improving drug solubility. In the present study, safe and effective ionic liquids for transdermal absorption were obtained as salts generated by a neutralization reaction between highly biocompatible aliphatic carboxylic acids (octanoic acid or isostearic acid) and aliphatic amines (diisopropanolamine or triisopropanolamine) (Medrx Co. Read More