Katla VR1, Syed R, Kuruva CS, Kuntrapakam HK, Chamarthi NR.
Chem Pharm Bull (Tokyo). 2013;61(1):25-32.A series of novel guanidine derivatives were synthesized in three steps and their anti-inflammatory activities in vitro and in vivo evaluated. 2-Aminopyridin-3-ol (1) was reacted with thiophosphoryl chloride (2) to give a monochloride (3). It was further reacted with cyanamide to afford the corresponding cyanamine (4), which was subsequently reacted with different heterocyclic amines to form the title compounds (5a-l). Read More