Akgün H1, Karamelekoğlu I, Berk B, Kurnaz I, Sarıbıyık G, Oktem S, Kocagöz T.
Bioorg Med Chem. 2012 Jul 1;20(13):4149-54. doi: 10.1016/j.bmc.2012.04.060. Epub 2012 May 4.Structurally modified phthalimide derivatives were prepared through condensation of phthalic and tetrafluorophthalic anhydride with selected sulfonamides with variable yields. All compounds were screened for their antimycobacterium activity against Mycobacterium tuberculosis H37Ra (ATCC 25177) using a micro broth dilution technique. The fluorinated derivatives (compounds 2c, 2d, 2f and 2h) had antimycobacterium activity comparable with classical sulfonamide drugs. Read More