Zhang M1, Kim YK1, Cui P1, Zhang J1, Qiao J1, He Y1, Lyu J1, Luo C1, Xing L1, Jiang H1.
Acta Pharm Sin B. 2016 Jul;6(4):336-43. doi: 10.1016/j.apsb.2016.03.010. Epub 2016 Apr 12.Biodegradable polyamines have long been studied as potential recombinant viral gene vectors. Spermine (SPE) is an endogenous tetra-amine with excellent biocompatibility yet poor gene condensation capacity. We have previously synthesized a polyspermine based on SPE and poly(ethylene glycol) (PEG) diacrylate (SPE-alt-PEG) for enhanced transfection performance, but the synthesized SPE-alt-PEG still lacked specificity towards cancer cells. Read More