Deng X1, Korogiannaki M1, Rastegari B1,2, Zhang J1, Chen M3, Fu Q1, Sheardown H1, Filipe CD1, Hoare T1.
ACS Appl Mater Interfaces. 2016 Aug 31;8(34):22064-73. doi: 10.1021/acsami.6b07433. Epub 2016 Aug 22.Improving the wettability of and reducing the protein adsorption to contact lenses may be beneficial for improving wearer comfort. Herein, we describe a simple "click" chemistry approach to surface functionalize poly(2-hydroxyethyl methacrylate) (pHEMA)-based contact lenses with hyaluronic acid (HA), a carbohydrate naturally contributing to the wettability of the native tear film. A two-step preparation technique consisting of laccase/TEMPO-mediated oxidation followed by covalent grafting of hydrazide-functionalized HA via simple immersion resulted in a model lens surface that is significantly more wettable, more water retentive, and less protein binding than unmodified pHEMA while maintaining the favorable transparency, refractive, and mechanical properties of a native lens. Read More