Li Z1,2,3, Dong J4, Zou T5, Du C2, Li S2, Chen C2, Liu R2, Wang K1,3.
Oncotarget. 2016 Dec 24. doi: 10.18632/oncotarget.14135. [Epub ahead of print]PURPOSE: Dexamethasone (Dex), a glucocorticoid (GC), is used as a pretreatment drug in cancer patients undergoing chemotherapy. Dex functions by binding to the glucocorticoid receptor (GR) to prevent allergic reactions and severe chemotherapeutic side effects such as nausea and vomiting. However, the mechanisms by which Dex causes chemoresistance remain unknown.METHODS: We used docetaxel and cisplatin to treat triple-negative breast cancer (TNBC) cells with or without Dex and assessed cell proliferation using a sulforhodamine B colorimetric (SRB) assay. Read More