Wang YT1, Cai XC1, Shi TQ1, Zhang YL1, Wang ZC1, Liu CH1, Zhu HL1.
Chem Biol Drug Des. 2016 Dec 29. doi: 10.1111/cbdd.12932. [Epub ahead of print]A series of new 1-phenylsulfonyl-2-(1-methylindol-3-yl)-benzimidazole derivatives were designed, synthesized and evaluated as potential inhibitors of tubulin polymerization and anthropic cancer cell lines. Among them, compound 33 displayed the most potent tubulin polymerization inhibitory activity in vitro (IC50 = 1.41 μM) and strong antiproliferative activities against A549, Hela, HepG2 and MCF-7 cell lines in vitro with GI50 value of 1. Read More