Miura Y1, Hui SP2, Shrestha R1, Hiruma T1, Takeda S1, Fuda H1, Ikegawa S1, Hirano K3, Chiba H1.
Steroids. 2016 Mar;107:1-9. doi: 10.1016/j.steroids.2015.12.004. Epub 2015 Dec 17.The accurate analysis of trace component in complex biological matrices requires the use of reliable standards. For liquid chromatography/mass spectrometry analysis, the stable isotope-labeled derivatives of the analyte molecules are the most appropriate internal standards. We report here the synthesis of (2β,3α,6-(2)H3)cholesteryl linoleate and oleate containing three non-exchangeable deuterium in the steroid ring. Read More