Rao CN1, Bentz C1, Reissig HU2.
Chemistry. 2015 Nov 2;21(45):15951-4. doi: 10.1002/chem.201502912. Epub 2015 Sep 14.New conditions for dearomatizing samarium-ketyl (hetero)arene cyclizations are reported. In many examples of these samarium diiodide-mediated reactions, lithium bromide and water can be used as additives instead of the carcinogenic and mutagenic hexamethylphosphoramide (HMPA). The best results were obtained for the cyclizations of N-acylated indole derivatives delivering the expected indolines in good yields and excellent diastereoselectivities. Read More