Tinajero-Trejo M1, Denby KJ2, Sedelnikova SE2, Hassoubah SA2, Mann BE3, Poole RK2.
J Biol Chem. 2014 Oct 24;289(43):29471-82. doi: 10.1074/jbc.M114.573444. Epub 2014 Sep 5.CO and NO are small toxic gaseous molecules that play pivotal roles in biology as gasotransmitters. During bacterial infection, NO, produced by the host via the inducible NO synthase, exerts critical antibacterial effects while CO, generated by heme oxygenases, enhances phagocytosis of macrophages. In Escherichia coli, other bacteria and fungi, the flavohemoglobin Hmp is the most important detoxification mechanism converting NO and O2 to the ion nitrate (NO3(-)). Read More