Takasuka H1, Hayashi S, Koyama M, Yasuda M, Aihara E, Amagase K, Takeuchi K.
J Pharmacol Exp Ther. 2011 Apr;337(1):293-300. doi: 10.1124/jpet.110.175216. Epub 2011 Jan 19.We examined the effect of the tricarbonyl-dichlororuthenium (II) dimer (CORM-2), a carbon monoxide (CO) donor, on duodenal HCO(3)(-) secretion in rats and investigated whether endogenous CO produced by heme oxygenase (HO) is involved in the regulation of this secretion. Under urethane anesthesia, a duodenal loop was perfused with saline, and HCO(3)(-) secretion was measured at pH 7.0 using a pH stat method. Read More