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Home > Product > Precious Metal Catalyst > (R)-Ru(OAc)2(SEGPHOS)

(R)-Ru(OAc)2(SEGPHOS) | CAS Number: 944450-48-0

Catalog Number
ACM944450480
Product Name
(R)-Ru(OAc)2(SEGPHOS)
Structure
CAS Number
944450-48-0
MDL Number
MFCD09753024
IUPAC Name
acetic acid;[4-(5-diphenylphosphanyl-1,3-benzodioxol-4-yl)-1,3-benzodioxol-5-yl]-diphenylphosphane;ruthenium
Synonyms
Diacetato[(R)-5,5′-bis(diphenylphosphino)-4,4′-bi-1,3-benzodioxole]ruthenium(II)
Molecular Weight
829.73
Exact Mass
830.07700
Molecular Formula
C42H34O8P2Ru
Purity
96%
Appearance
dark yellow powder
InChIKey
OISNHBFITMBIMI-UHFFFAOYSA-N
H-Bond Donor
2
H-Bond Acceptor
8
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1Direct asymmetric reductive amination.

Steinhuebel D1, Sun Y, Matsumura K, Sayo N, Saito T.

J Am Chem Soc. 2009 Aug 19;131(32):11316-7. doi: 10.1021/ja905143m.

Asymmetric reductive amination of beta-keto amides catalyzed by the chiral catalyst Ru(OAc)(2)((R)-dm-segphos) produces unprotected beta-amino amides with high yields and high enantioselectivities (94.7-99.5% ee). This "one-pot" methodology is general in substrate scope and has been successfully employed to produce sitagliptin with 99.5% ee and 91% assay yield. The excellent reaction efficiency is attributed to the remarkable tolerance to high concentrations of ammonium ion, the high chemoselectivity, and the high enantioselectivity (99.5% ee) of the Ru catalyst system.

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Tel:1-201-478-8534
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Address: Suite 212, Waverly Plaza, 755 Waverly Avenue, Holtsville, NY 11742, USA