Catalog Number
ACM129689287-1
Description
ZD7114, also known as ICI-D7114, is a selective adrenoceptor agonist of brown fat and thermogenesis. ICI D7114 stimulates thermogenesis at doses that have little effect on beta 1 or beta 2 adrenoceptors. Treatment with ICI D7114 activates BAT and thermogenesis even in species and situations where the intrinsic capacity is low. ICI D7114 has beneficial effects in animal models of obesity and disturbed glucose and lipid homeostasis.
Synonyms
ZD 7114 hydrochloride; ZD7114 HCl; ZD7114; ZD-7114; ZD 7114; ICI-D7114; ICI-D-7114; ICI-D 7114
IUPAC Name
Acetamide, 2-(4-(2-((2-hydroxy-3-phenoxypropyl)amino)ethoxy)phenoxy)-N-(2-methoxyethyl)-, (S)-, hydrochloride
Molecular Formula
C22H31ClN2O6
Canonical SMILES
O=C(NCCOC)COC1=CC=C(OCCNC[C@H](O)COC2=CC=CC=C2)C=C1.[H]Cl
InChI
InChI=1S/C22H30N2O6.ClH/c1-27-13-12-24-22(26)17-30-21-9-7-20(8-10-21)28-14-11-23-15-18(25)16-29-19-5-3-2-4-6-19;/h2-10,18,23,25H,11-17H2,1H3,(H,24,26);1H/t18-;/m0./s1
InChI Key
KCAMZVQSGDBGGF-FERBBOLQSA-N
Solubility
To be determined
Shelf Life
>2 years if stored properly
Storage
Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
Alternative CAS
129689-30-1 (free base); 129689-28-7 (HCl)
Drug Formulation
To be determined
Elemental Analysis
C, 58.08; H, 6.87; Cl, 7.79; N, 6.16; O, 21.10
HS Tariff Code
2934.99.9001
Shipping
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Stock Solution Storage
0-4 °C for short term (days to weeks), or -20 °C for long term (months).
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