Catalog Number
ACM120241794
Description
3-TYP is an inhibitor of SIRT3.
Synonyms
3-TYP; 3TYP; 3 TYP
IUPAC Name
3-(1H-1,2,3-triazol-4-yl) pyridine
Canonical SMILES
C1(C2=CNN=N2)=CC=CN=C1
InChI
InChI=1S/C7H6N4/c1-2-6(4-8-3-1)7-5-9-11-10-7/h1-5H,(H,9,10,11)
InChI Key
VYXFEFOIYPNBFK-UHFFFAOYSA-N
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Storage
Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
Biological Target
3-TYP is a selective SIRT3 inhibitor, with an IC50 of 16 nM, more potent over SIRT1 (IC50=88 nM), SIRT2 (IC50=92 nM).
Drug Formulation
This drug may be formulated in DMSO
Elemental Analysis
C, 57.53; H, 4.14; N, 38.34
HS Tariff Code
2934.99.9001
In Vitro Activity
3-TYP inhibits melatonin-enhanced SIRT3 activity but does not affect SIRT3 protein expression. 3-TYP pretreatment reverses the protective effects of melatonin on cadmium (Cd)-induced mitochondrial-derived O2·- production and autophagic cell death. 3-TYP significantly attenuates melatonin-induced increases in deacetylated-SOD2 expression and SOD2 activity in HepG2 cells exposed to Cd.
Reference: Autophagy. 2015;11(7):1037-51. https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/26120888/
In Vivo Activity
3-TYP (50 mg/kg, i.p.) does not significantly influence the LVEF, LVFS, infarct size, serum LDH levels, apoptosis, and oxidative stress compared with those of the Sham group. Moreover, 3-TYP has little effect on gp91phox, Nrf2, NQO 1, Bax, Bcl-2, Caspase-3, and cleaved Caspase-3 expression levels, compared with the Sham group. 3-TYP significantly decreases SIRT3 activity and increases the acetylation of SOD2 compared with that in the control group, without influencing SIRT3 expression. 3-TYP attenuates the cardioprotective effects of melatonin by decreasing the LVEF and LVFS after 24 hour of reperfusion. 3-TYP also increases the infarct size, serum LDH levels, and apoptotic ratio compared with those in the IR+Mel group.
Reference: J Pineal Res. 2017 Sep;63(2). https://doi.org/10.1111/jpi.12419
Shipping
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Stock Solution Storage
0-4 °C for short term (days to weeks), or -20 °C for long term (months).
Download
