tert-Butyl[s-(r*,r*)]-(-)-(1-oxiranyl-2-phenylethyl)carbamate

• CAS: 98737-29-2
• Catalog Number: ACM98737292
• Category: Other Products
• Molecular Weight: 263.34
• Molecular Formula: C₁₅H₂₁NO₃
• Synonyms: 98737-29-2, (2S,3S)-1,2-Epoxy-3-(Boc-amino)-4-phenylbutane, (2S,3S)-N-t-Boc-3-amino-1,2-epoxy-4-phenylbutane, (2S,3S)-1,2-Epoxy-3-(tert-butoxycarbonylamino)-4-phenylbutane, tert-Butyl ((S)-1-((S)-oxiran-2-yl)-2-phenylethyl)carbamate, 286019-82-7, tert-Butyl [(S)-1-[(S)-Oxiran-2-yl]-2-phenylethyl]carbamate, Tert-butyl N-[(1S)-1-[(2S)-oxiran-2-yl]-2-phenyl-ethyl]carbamate, tert-Butyl [S-(R, KSC523O6B, 476951_ALDRICH, CTK4C3760, 143688-65-7, ACT02842, ANW-40956, ZINC02567352, AKOS015894820, AG-D-86388, AG-L-62739, BD23336
• IUPAC Name: tert-butyl N-[(1S)-1-[(2S)-oxiran-2-yl]-2-phenylethyl]carbamate
• Canonical SMILES: CC(C)(C)OC(=O)NC(CC1=CC=CC=C1)C2CO2
• InChI Key: NVPOUMXZERMIJK-QWHCGFSZSA-N
• Boiling Point: 398.837ºC at 760 mmHg
• Melting Point: 125-127ºC
• Flash Point: 195.01ºC
• Density: 1.118g/cm³
• Appearance: off-white solid
• EC Number: 619-373-1
• Exact Mass: 263.15200
• Hazard Statements: F,Xi
• H-Bond Acceptor: 3
• H-Bond Donor: 1
• Safety Description: 7/9-16-26-36/37/39

Synthetic Use

Upstream Synthesis Route 1

• 107202-43-7

• 98760-08-8
• 98737-29-2

Reference: [1]Romeo, Sergio; Rich, Daniel H.
[Tetrahedron Letters, 1994, vol. 35, # 28, p. 4939 - 4942]
[2]Rich; Sun; Vara Prasad; Pathiasseril; Toth; Marshall; Clare; Mueller; Houseman
[Journal of Medicinal Chemistry, 1991, vol. 34, # 3, p. 1222 - 1225]
[3]Luly, Jay R.; Dellaria, Joseph F.; Plattner, Jacob J.; Soderquist, Jeffrey L.; Yi, Nwe
[Journal of Organic Chemistry, 1987, vol. 52, # 8, p. 1487 - 1492]
[4]Location in patent: scheme or table
Paige Souder; Evans, Zachary M.; Driver, Joshua A.; Pozzo, Eric J.; Lampkins, Andrew J.
[Tetrahedron Letters, 2011, vol. 52, # 51, p. 6908 - 6910]
[5]Blacker, A. John; Roy, Mita; Hariharan, Sivaramkrishanan; Headley, Catherine; Upare, Abhay; Jagtap, Ashutosh; Wankhede, Karuna; Mishra, Sushil Kumar; Dube, Dagadu; Bhise, Sanjay; Vishwasrao, Sandesh; Kadam, Nitin
[Organic Process Research and Development, 2011, vol. 15, # 2, p. 331 - 338]

Upstream Synthesis Route 2

• 107202-43-7

• 98737-29-2

Reference: [1]Liao, Yung-Feng; Wang, Bo-Jeng; Hsu, Wen-Ming; Lee, Hsinyu; Liao, Chia-Yin; Wu, Shin-Ying; Cheng, Hui-Ting; Hu, Ming-Kuan
[Molecular Pharmacology, 2007, vol. 71, # 2, p. 588 - 601]
[2]Branalt, Jonas; Kvarnstroem, Ingemar; Classon, Bjoern; Samuelsson, Bertil; Nillroth, Ulrika; Danielson, U. Helena; Karlen, Anders; Hallberg, Anders
[Tetrahedron Letters, 1997, vol. 38, # 19, p. 3483 - 3486]
[3]Jaudzems, Kristaps; Tars, Kaspars; Maurops, Gundars; Ivdra, Natalija; Otikovs, Martins; Leitans, Janis; Kanepe-Lapsa, Iveta; Domraceva, Ilona; Mutule, Ilze; Trapencieris, Peteris; Blackman, Michael J.; Jirgensons, Aigars
[ACS Medicinal Chemistry Letters, 2014, vol. 5, # 4, p. 373 - 377]

Downstream Synthesis Route 1

• 98737-29-2

• 206361-99-1

Reference: [1]Ghosh, Arun K.; Leshchenko, Sofiya; Noetzel, Marcus
[Journal of Organic Chemistry, 2004, vol. 69, # 23, p. 7822 - 7829]

* For details of the synthesis route, please refer to the original source to ensure accuracy.