Sodium Picosulfate with Magnesium Citrate (SPMC) as Bowel Prep for Colonoscopy
Kim, Hyun Gun, et al. Gut and liver, 2015, 9(4), 494.
Colonoscopy is considered the most effective screening procedure for colorectal cancer. Polyethylene glycol (PEG) is widely accepted as a standard bowel preparation regimen, but its unpleasant taste and high intake lead to low compliance rates and poor cleaning quality. Sodium picosulfate with magnesium citrate (SPMC) has emerged as a low-volume, dual-action bowel cleanser. The study investigated the cleaning efficacy, safety, and tolerability of SPMC compared with traditional PEG formulations. Results suggested that SPMC is a good alternative to traditional high-volume PEG for intestinal preparation.
Trial Design
· The study was a multicenter, randomized, single-blind, non-inferiority trial conducted in 13 institutions in Korea and involved participants aged 20 to 75 undergoing selective outpatient colonoscopy.
· Exclusion criteria included a history of prior colorectal surgery, intestinal obstruction, severe constipation, inflammatory bowel disease, pregnancy, cognitive impairment, and renal impairment.
· Patients were allocated to receive either split-dose SPMC with bisacodyl or split-dose PEG using randomization tables generated by an independent biostatistician.