Catalog Number
ACM286369388
Description
S 14506 is a highly potent selective 5-HT1A receptor full agonist (pKi values are 9.0, 6.6, 7.5, 6.6 and < 6.0 for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT2 and 5-HT3 receptors respectively). It potentially binds between the agonist binding site and the G protein interaction switch site, affecting the activation mechanism, and may display positive cooperativity.
Synonyms
S 14506 HCl; S14506HCl; S14506 HCl; S-14506
IUPAC Name
4-Fluoro-N-[2-[4-(7-methoxy-1-naphthalenyl)-1-piperazinyl]ethyl]benzamide hydrochloride
Molecular Formula
C24H27ClFN3O2
Canonical SMILES
O=C(NCCN1CCN(C2=C3C=C(OC)C=CC3=CC=C2)CC1)C4=CC=C(F)C=C4.[H]Cl
InChI
InChI=1S/C24H26FN3O2.ClH/c1-30-21-10-7-18-3-2-4-23(22(18)17-21)28-15-13-27(14-16-28)12-11-26-24(29)19-5-8-20(25)9-6-19;/h2-10,17H,11-16H2,1H3,(H,26,29);1H
InChI Key
HWLZKPKZVOLFGK-UHFFFAOYSA-N
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Storage
Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
Alternative CAS
135722-25-7 (free base); 286369-38-8 (HCl)
Drug Formulation
This drug may be formulated in DMSO
Elemental Analysis
C, 64.93; H, 6.13; Cl, 7.99; F, 4.28; N, 9.47; O, 7.21
HS Tariff Code
2934.99.9001
Shipping
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Stock Solution Storage
0-4 °C for short term (days to weeks), or -20 °C for long term (months).
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