o6-Benzylguanine

• Catalog Number: ACM19916735
• Product Name: o6-Benzylguanine
• CAS: 19916-73-5
• Category: Inhibitors
• Description: O6-Benzylguanine, a guanine analog, is the DNA repair enzyme O6-alkylguanine-DNA alkyltransferase (MGMT/AGT) inhibitor. O6-Benzylguanine acts as an AGT substrate, which transfers its benzyl group to the AGT cysteine residue, thereby irreversibly inactivating AGT and preventing DNA repair. O6-Benzylguanine induces tumor cell apoptosis. Antineoplastic activity.
• Molecular Weight: 241.25
• Molecular Formula: C₁₂H₁₁N₅O
• Canonical SMILES: NC(N=C1OCC2=CC=CC=C2)=NC3=C1NC=N3
• Appearance: Solid
• Storage: 4°C, protect from light*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light).
• Shipping: Can be shipped at room temperature, where not in use may vary.