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Catalog Number
ACM152946684
Product Name
Nolatrexed dihydrochloride
Structure
CAS
152946-68-4
Category
Inhibitors
Description
Nolatrexed dihydrochloride (AG 337) is a non-competitive lipophilic inhibitor of thymidylate synthase, interacts at the folate cofactor binding site of the enzyme, with a Ki of 11 nM for human thymidylate synthase. Nolatrexed dihydrochloride (AG 337) induces cell cycle arrest in S phase of cancer cells. Anti-cancer activity.