Specification
Description
NAI-N3 is a probe for icSHAPE (in vivo click selective 2'-hydroxyl acylation and profiling experiment). It acylates the 2'-OH in ssRNA and enables RNA structure profiling in vivo and ex vivo for all four bases. NAI-N3 can be used for site-specific RNA acylation using the RAIL (RNA Acylation at Induced Loops) method or in Apta-Seq to discover new aptamers in selected pools.
Synonyms
NAI-N3; NAIN3; NAI N3
IUPAC Name
(2-(azidomethyl)pyridin-3-yl)(1H-imidazol-1-yl)methanone
Canonical SMILES
[N-]=[N+]=NCC1=C(C=CC=N1)C(N2C=CN=C2)=O
InChI
InChI=1S/C10H8N6O/c11-15-14-6-9-8(2-1-3-13-9)10(17)16-5-4-12-7-16/h1-5,7H,6H2
InChI Key
QPSQVTFTPHUCEH-UHFFFAOYSA-N
Solubility
To be determined
Shelf Life
>2 years if stored properly
Storage
Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
Drug Formulation
to be determined
Elemental Analysis
C, 52.63; H, 3.53; N, 36.83; O, 7.01
HS Tariff Code
2934.99.9001
Shipping
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Stock Solution Storage
0-4 °C for short term (days to weeks), or -20 °C for long term (months).