Catalog Number
ACM144120547
Product Name
Fmoc-Glu-OAll
Description
Orthogonally-protected building block for the synthesis of head-to-tail cyclic peptides by Fmoc SPPS.The α-allyl ester can be selectively removed in the presence of Fmoc- and tBu-based protecting groups by treatment with Pd(Ph3P)4/ CHCl3/AcOH/NMM, thereby facilitating the synthesis of branched esters and amides, and lactones and lactams incorporating a glutamyl unit.
Synonyms
Fmoc-Glu-OAll, N-α-Fmoc-L-glutamic acid α-allyl ester
Molecular Formula
C23H23NO6
InChI
1S/C23H23NO6/c1-2-13-29-22(27)20(11-12-21(25)26)24-23(28)30-14-19-17-9-5-3-7-15(17)16-8-4-6-10-18(16)19/h2-10,19-20H,1,11-14H2,(H,24,28)(H,25,26)/t20-/m0/s1
InChI Key
ORKKMGRINLTBPC-FQEVSTJZSA-N
Application
Peptide synthesis.
Assay
≥95.0% (acidimetric)
≥98% (TLC)
≥98.0% (HPLC)
Functional Group
carboxylic acid
Reaction Suitability
reaction type: Fmoc solid-phase peptide synthesis
Type
Unlabeled Standard Amino Acids, Glutamic Acid (Glu)