Catalog Number
ACM132327801
Product Name
Fmoc-Gln(Trt)-OH
Description
High purity Fmoc-protected amino acid for research and process production of peptides, with very low levels of dipeptide, free-amino acids and acetic acid impurities.
Fmoc-Gln(Trt)-OH has good solubility properties in most organic solvents, and its use has been shown to result in significantly purer peptides than other derivatives used for the introduction of Gln. Coupling can be performed by standard procedures. The trityl-protecting group is normally removed by 95% TFA in 1-3 hours, with no alkylation of Trp.
Literature references
P. Sieber, et al. (1991) Tetrahedron Lett., 32, 739
Synonyms
Fmoc-Gln(Trt)-OH, N-α-Fmoc-N-γ-trityl-L-glutamine
Molecular Formula
C39H34N2O5
InChI
1S/C39H34N2O5/c42-36(41-39(27-14-4-1-5-15-27,28-16-6-2-7-17-28)29-18-8-3-9-19-29)25-24-35(37(43)44)40-38(45)46-26-34-32-22-12-10-20-30(32)31-21-11-13-23-33(31)34/h1-23,34-35H,24-26H2,(H,40,45)(H,41,42)(H,43,44)/t35-/m0/s1
InChI Key
WDGICUODAOGOMO-DHUJRADRSA-N
Application
Peptide synthesis.
Assay
≥93.0% (acidimetric)
≥98% (TLC)
≥99.0% (HPLC)
Reaction Suitability
reaction type: Fmoc solid-phase peptide synthesis
Storage Temperature
-10 to -25℃
Type
Unlabeled Standard Amino Acids, Glutamine (Gln)