Catalog Number
ACM67436139
Product Name
Fmoc-Cys(tBu)-OH
Description
The side-chain tBu group is stable to TFA and iodine oxidation. Treatment with MeSiCl3/PhSOPh removes t-Bu and cyclizes in one step without scrambling existing disulphide bonds. Removed with Hg(II) to give cysteinyl peptides.
Synonyms
Fmoc-Cys(tBu)-OH, N-α-Fmoc-S-t.-butyl-L-cysteine
InChI
1S/C22H25NO4S/c1-22(2,3)28-13-19(20(24)25)23-21(26)27-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,23,26)(H,24,25)
InChI Key
IXAYZHCPEYTWHW-UHFFFAOYSA-N
Application
Peptide synthesis.
Assay
≥97.0% (acidimetric)
≥98% (TLC)
≥98.0% (HPLC)
Reaction Suitability
reaction type: Fmoc solid-phase peptide synthesis