Fmoc-Cys(STmp)-OH

• Catalog Number: ACM1403834741
• Product Name: Fmoc-Cys(STmp)-OH
• CAS: 1403834-74-1
• Category: Amino Acids
• Description: Fmoc-Cys(STmp)-OH is a novel new tool for the regioselective synthesis of multiple disulfide bridged peptides by Fmoc SPPS. The STmp group is stable to piperidine but is extremely easy to remove by mild thiolysis. Albericio has reported removing four STmp groups on the solid phase with only three 5 minute treatments of 0.1 M N-methylmorpholine (NMM) in DMF containing 5% DTT.
• Synonyms: Fmoc-Cys(STmp)-OH, N-α-Fmoc-S-2,4,6-trimethoxyphenylthio-L-cysteine
• IUPAC Name: (2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[(2,4,6-trimethoxyphenyl)disulfanyl]propanoic acid
• Molecular Weight: 541.64
• Molecular Formula: C27H27NO7S2
• Canonical SMILES: COC1=CC(=C(C(=C1)OC)SSCC(C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24)OC
• InChI: 1S/C27H27NO7S2/c1-32-16-12-23(33-2)25(24(13-16)34-3)37-36-15-22(26(29)30)28-27(31)35-14-21-19-10-6-4-8-17(19)18-9-5-7-11-20(18)21/h4-13,21-22H,14-15H2,1-3H3,(H,28,31)(H,29,30)/t22-/m0/s1
• InChI Key: GADCBXMSWHDNAU-QFIPXVFZSA-N
• Boiling Point: 742.3±60.0 ℃at 760 mmHg
• Flash Point: 402.7±32.9 ℃
• Density: 1.4±0.1 g/cm³
• Application: Peptide synthesis.
• Exact Mass: 541.122864
• Form: powder
• Functional Group: thiol
• LogP: 6.61
• MDL Number: MFCD27957369
• Quality Level: 200
• Reaction Suitability: reaction type: Fmoc solid-phase peptide synthesis
• Refractive Index: 1.669
• Storage Temperature: 15-25℃
• Vapor Pressure: 0.0±2.6 mmHg at 25℃