Specification
Description
Dov-Val-Dil-OH is a useful chemical intermediate for synthesis of auristatin-related compounds, such as Monomethyl auristatin E (MMAE), Auristatins are antimitotic agents which inhibits cell division by blocking the polymerisation of tubulin.
Synonyms
Dov-Val-Dil-OH TFA; Dov-Val-Dil-OH; Dov-Val-Dil-OH; dimethylVal-Val-Dil-COOH
IUPAC Name
(3R,4S,5S)-4-((S)-2-((S)-2-(dimethylamino)-3-methylbutanamido)-N,3-dimethylbutanamido)-3-methoxy-5-methylheptanoic acid trifluoroacetic acid
Canonical SMILES
CC[C@H](C)[C@H](N(C)C([C@@H](NC([C@@H](N(C)C)C(C)C)=O)C(C)C)=O)[C@H](OC)CC(O)=O.O=C(O)C(F)(F)F
InChI
InChI=1S/C22H43N3O5.C2HF3O2/c1-11-15(6)20(16(30-10)12-17(26)27)25(9)22(29)18(13(2)3)23-21(28)19(14(4)5)24(7)8;3-2(4,5)1(6)7/h13-16,18-20H,11-12H2,1-10H3,(H,23,28)(H,26,27);(H,6,7)/t15-,16+,18-,19-,20-;/m0./s1
InChI Key
QUIQWXWGYURKKL-NKPYJPHDSA-N
Solubility
To be determined
Shelf Life
>2 years if stored properly
Storage
Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
Alternative CAS
133120-89-5 (free base); 133120-90-8 (TFA); 2247145-33-9 (HCl)
Drug Formulation
To be determined
Elemental Analysis
C, 53.03; H, 8.16; F, 10.48; N, 7.73; O, 20.60
HS Tariff Code
2934.99.9001
Shipping
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Stock Solution Storage
0-4 °C for short term (days to weeks), or -20 °C for long term (months).