Catalog Number
ACM104872426
Description
DOTMA is one of the first cationic lipid used for gene transfection. DOTMA is an effective transfection agent in vitro and in vivo. DOTMA carries a positive charge on the surface of liposomes which condenses anionic nucleic acids and promotes efficient interactions between the cell membrane and the liposome.
Synonyms
DOTMA; 1,2-di-O-octadecenyl-3-trimethylammonium propane
IUPAC Name
N,N,N-trimethyl-2,3-bis(((Z)-octadec-9-en-1-yl)oxy)propan-1-aminium chloride
Molecular Formula
C42H84ClNO2
Canonical SMILES
CCCCCCCC/C=C\CCCCCCCCOCC(OCCCCCCCC/C=C\CCCCCCCC)C[N+](C)(C)C.[Cl-]
InChI
InChI=1S/C42H84NO2.ClH/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-38-44-41-42(40-43(3,4)5)45-39-37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2;/h20-23,42H,6-19,24-41H2,1-5H3;1H/q+1;/p-1/b22-20-,23-21-;
InChI Key
LDGWQMRUWMSZIU-LQDDAWAPSA-M
Solubility
To be determined
Shelf Life
>2 years if stored properly
Storage
Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
Alternative CAS
717090-94-3 (cation);104872-42-6 (chloride)
Drug Formulation
To be determined
Elemental Analysis
C, 75.23; H, 12.63; Cl, 5.29; N, 2.09; O, 4.77
HS Tariff Code
2934.99.9001
Shipping
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Stock Solution Storage
0-4 °C for short term (days to weeks), or -20 °C for long term (months).
Storage Temperature
Dry, dark and at 0 - 4 °C for short term (days to weeks) or -20 °C for long term (months to years)
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