Catalog Number
ACM537034176
Description
BML-210, also known as CAY10433, is HDAC inhibitor. BML-210 induces growth inhibition and apoptosis and regulates HDAC and DAPC complex expression levels in cervical cancer cells. BML-210 can inhibit cell growth and induce apoptosis in cervical cancer cells, what correlates with down-regulation of HDAC class I and II and changes in the DAPC expression levels.
Synonyms
BML-210; BML 210; BML210; CAY10433; CAY-10433; CAY 10433
IUPAC Name
N-(2-aminophenyl)-N'-phenyl-octanediamide
Molecular Formula
C20H25N3O2
Canonical SMILES
O=C(NC1=CC=CC=C1N)CCCCCCC(NC2=CC=CC=C2)=O
InChI
InChI=1S/C20H25N3O2/c21-17-12-8-9-13-18(17)23-20(25)15-7-2-1-6-14-19(24)22-16-10-4-3-5-11-16/h3-5,8-13H,1-2,6-7,14-15,21H2,(H,22,24)(H,23,25)
InChI Key
RFLHBLWLFUFFDZ-UHFFFAOYSA-N
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Storage
Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
Biological Target
BML-210 is a novel HDAC inhibitor.
Drug Formulation
This drug may be formulated in DMSO
Elemental Analysis
C, 70.77; H, 7.42; N, 12.38; O, 9.43
HS Tariff Code
2934.99.9001
In Vitro Activity
BML-210 inhibited cell proliferation and growth inhibition of NB4 cells in a dose- and time-dependent manner (Figure 1A,B). 10 μM BML-210 inhibited growth of NB4 cells up to 44% and 77% at day one and two, respectively (Figure 1A). The 10 μM BML-210 treatment also caused anti-proliferative effect: the viable cell number in culture was 88% (after 24 h) and 57% (after 48 h) (Figure 1B). An even stronger effect was observed after treatment with 20 μM BML-210: 67% of viable cells were detected at 24 h point of treatment and growth inhibition up to 90% at 48 h point (Figure 1A,B).
Reference: Int J Mol Sci. 2015 Aug; 16(8): 18252-18269. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581243/
Shipping
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Stock Solution Storage
0-4 °C for short term (days to weeks), or -20 °C for long term (months).
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