Antunes AM1, Novais DA, da Silva JL, Santos PP, Oliveira MC, Beland FA, Marques MM.
Org Biomol Chem. 2011 Oct 26;9(22):7822-35. doi: 10.1039/c1ob06052j. Epub 2011 Oct 3.Nevirapine (11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one, NVP) is a non-nucleoside HIV-1 reverse transcriptase inhibitor used to prevent mother-to-child transmission of the virus. However, severe hepatotoxicity and serious adverse cutaneous effects have raised concerns about the safety of NVP administration. NVP metabolism yields several phenol-type derivatives conceivably capable of undergoing further metabolic oxidation to electrophilic quinoid species that could react with bionucleophiles. Read More