Pacuła AJ1, Kaczor KB2, Wojtowicz A2, Antosiewicz J2, Janecka A3, Długosz A3, Janecki T4, Ścianowski J5.
Bioorg Med Chem. 2016 Oct 18. pii: S0968-0896(16)30995-6. doi: 10.1016/j.bmc.2016.10.018. [Epub ahead of print]A series of N-alkyl benzisoselenazol-3(2H)-ones has been obtained and transformed to corresponding diselenides by the reduction with sodium borohydride. Additionally, efficient methodology for the oxidative Se-N bond formation by potassium iodate has been presented, new conversion of diselenide to benzisoselenazolone was observed. The GPx-like activity of all synthetized derivatives has been evaluated by NMR. Read More