Morales-Cano D1, Moreno L1, Barreira B1, Briones AM2, Pandolfi R1, Moral-Sanz J1, Callejo M1, Mondejar-Parreño G1, Cortijo J3, Salaices M2, Duarte J4, Perez-Vizcaino F1, Cogolludo A5.
Clin Sci (Lond). 2016 Oct 1;130(20):1823-36. doi: 10.1042/CS20160141. Epub 2016 Jul 13.PPARβ/δ activation protects against endothelial dysfunction in diabetic models. Elevated glucose is known to impair cAMP-induced relaxation and Kv channel function in coronary arteries (CA). Herein, we aimed to analyse the possible protective effects of the PPARβ/δ agonist GW0742 on the hyperglycaemic-induced impairment of cAMP-induced relaxation and Kv channel function in rat CA. As compared with low glucose (LG), incubation under high glucose (HG) conditions attenuated the relaxation induced by the adenylate cyclase activator forskolin in CA and this was prevented by GW0742. Read More