Pflaum M1, Kühn-Kauffeldt M2, Schmeckebier S3, Dipresa D3, Chauhan K3, Wiegmann B4, Haug RJ5, Schein J2, Haverich A6, Korossis S7.
Acta Biomater. 2016 Dec 9. pii: S1742-7061(16)30685-7. doi: 10.1016/j.actbio.2016.12.017. [Epub ahead of print]Fouling on the gas-exchange hollow-fiber membrane (HFM) of extracorporeal membrane oxygenation (ECMO) devices by blood components and pathogens represents the major hurdle to their long-term application in patients with lung deficiency or unstable hemodynamics. Although patients are treated with anticoagulants, deposition of blood proteins onto the membrane surface may still occur after few days, leading to insufficient gas transfer and, consequently, to device failure. Read More