Parisi N1, Paz-Alvarez M1, Matts PJ2, Lever R1, Hadgraft J1, Lane ME3.
Int J Pharm. 2016 Jun 15;506(1-2):332-9. doi: 10.1016/j.ijpharm.2016.04.069. Epub 2016 Apr 26.Hexamidine diisethionate (HEX D) has been used for its biocidal actions in topical preparations since the 1950s. Recent data also suggest that it plays a beneficial role in skin homeostasis. To date, the extent to which this compound penetrates the epidermis has not been reported nor how its topical delivery may be modulated. In the present work we set out to characterise the interaction of HEX D with the skin and to develop a range of simple formulations for topical targeting of the active. Read More