Aguado BA1, Caffe JR1, Nanavati D2, Rao SS3, Bushnell GG4, Azarin SM5, Shea LD6.
Acta Biomater. 2016 Mar;33:13-24. doi: 10.1016/j.actbio.2016.01.043. Epub 2016 Feb 1.Metastatic tumor cells colonize the pre-metastatic niche, which is a complex microenvironment consisting partially of extracellular matrix (ECM) proteins. We sought to identify and validate novel contributors to tumor cell colonization using ECM-coated poly(ε-caprolactone) (PCL) scaffolds as mimics of the pre-metastatic niche. Utilizing orthotopic breast cancer mouse models, fibronectin and collagen IV-coated scaffolds implanted in the subcutaneous space captured colonizing tumor cells, showing a greater than 2-fold increase in tumor cell accumulation at the implant site compared to uncoated scaffolds. Read More