Chen SH, Chang Y, Ishihara K.
Langmuir. 2016 Nov 1. [Epub ahead of print]To conquer thrombogenic reactions of hydrocarbon-based biomaterials in clinical blood treatment, we introduce a model study of a surface zwitterionization of polypropylene (PP) substrate using a set of well-defined copolymers for controlling the adhesion of blood cells in vitro. Random and block copolymers containing zwitterionic units of 2-methacryloyloxyethyl phosphorylcholine (MPC), [3-(methacryloylamino)propyl] dimethyl(3-sulfopropyl)ammonium hydroxide inner salt (SBAA), or non-ionic units of 2-hydroxyethyl methacrylate (HEMA) with a controlled hydrophobic segment of 70% n-butyl methacrylate (BMA) units in these polymers were synthesized by reversible addition-fragmentation chain transfer polymerization. Read More