Wang W1, Kapur A1, Ji X1, Zeng B1,2, Mishra D1, Mattoussi H1.
Bioconjug Chem. 2016 Sep 21;27(9):2024-36. doi: 10.1021/acs.bioconjchem.6b00309. Epub 2016 Aug 23.We detail the design of hydrophilic metal-coordinating ligands and their use for the effective coating of luminescent quantum dots (QDs). The ligand design exploits the specific, reagent-free nucleophilic addition reaction of amine-modified molecules toward maleic anhydride to introduce several lipoic acid metal anchors, hydrophilic zwitterion moieties, and specific reactive groups along a poly(isobutylene-alt-maleic anhydride) (PIMA) chain. Read More