Zeng N1, Hu Q, Liu Z, Gao X, Hu R, Song Q, Gu G, Xia H, Yao L, Pang Z, Jiang X, Chen J, Fang L.
Int J Pharm. 2012 Mar 15;424(1-2):58-66. doi: 10.1016/j.ijpharm.2011.12.058. Epub 2012 Jan 8.Lipid-based liquid crystalline nanoparticles (LCNPs) have attracted growing interest as a new drug nanocarrier system for improving bioavailability for both hydrophilic and hydrophobic drugs. In this study, self-assembled LCNPs based on soy phosphatidyl choline and glycerol dioleate, which was known possessing low toxicity and negligible hemolysis, were prepared using poly(ethylene glycol)-grafted 1,2-distearoyl-sn-glycero-3-phosphatidylethanolamine (DSPE-PEG) as the dispersing agent. Read More