Jose J1, Charyulu RN1.
Int J Pharm Investig. 2016 Apr-Jun;6(2):123-7. doi: 10.4103/2230-973X.177833.INTRODUCTION: The potent antifungal agent amphotericin B (AmB) is not freely soluble in water. The clinical use of AmB is limited by nephrotoxicity and poor water solubility. Polyamidoamine (PAMAM) dendrimer offers an identical carrier for drug binding that has the capacity to attach and discharge drugs in numerous ways.MATERIALS AND METHODS: In this research work, we explored the potential of PAMAM dendrimers to improve the solubility of AmB. Read More