Sadler PJ1, Sanchez-Cano C, Romero-Canelon I, Yang Y, Hands-Portman I, Bohic S, Cloetens P.
Chemistry. 2016 Dec 24. doi: 10.1002/chem.201605911. [Epub ahead of print]A variety of transition metal complexes exhibit anticancer activity, but their target sites in cells need to be identified and mechanisms of action elucidated. Here we show that the sub-cellular distribution of [(ŋ6-p-cym)Os(Azpy-NMe2)I]+ (p-cym = p-cymene, Azpy-NMe2 = 2-(p-((dimethylamino]phenylazo)pyridine)) , a promising drug candidate, can be mapped in human ovarian cancer cells at pharmacological concentrations using a synchrotron X-ray fluorescence nanoprobe (SXRFN). Read More