Bae HE1, Mortensen JS2, Ribeiro O3, Du Y4, Ehsan M1, Kobilka BK4, Loland CJ2, Byrne B3, Chae PS1.
Chem Commun (Camb). 2016 Oct 4;52(81):12104-12107.A novel class of detergents, designated tandem neopentyl glycol maltosides (TNMs), were evaluated with four target membrane proteins. The best detergent varied depending on the target, but TNM-C12L and TNM-C11S were notable for their ability to confer increased membrane protein stability compared to DDM. These agents have potential for use in membrane protein research.