Liu B1,2,3,4, Wang J1,2,3,4, Li M1,2,3,4, Yuan Q1,2,3,4, Xue M1,2,3,4, Xu F1,2,3,4, Chen Y1,2,3,4.
Oncotarget. 2016 Dec 27. doi: 10.18632/oncotarget.14297. [Epub ahead of print]Although hyperglycemia is causally related to adverse outcomes after myocardial ischemia/reperfusion (I/R), the underlying mechanisms are largely unknown. Here, we investigated whether excessive O-linked-N-acetylglucosamine (O-GlcNAc) modification of acetaldehyde dehydrogenase 2 (ALDH2), an important cardioprotective enzyme, was a mechanism for the hyperglycemic exacerbation of myocardial I/R injury. Read More